Polyclonal Antibody to APH1A
Catalogue Number: 11-10036-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | APH1A||PSF||CGI-78||UNQ579/PRO1141 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant APH1A protein (amino acids 11-245) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: APH1A also known as Anterior pharynx-defective 1, is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. The gamma-secretase complex is required for the intramembrane proteolysis of APP (amyloid-beta precursor protein) and Notch. APH1A is essential for gamma-cleavage of APP to enable the intracellular domain to travel to the nucleus. APH1A satisfies three major criteria for a subunit of the gamma-secretase complex in mammalian cells. First, endogenous APH1A, nicastrin, and the presenilin NTF:CTF heterodimers physically interact with each other in vivo and under the conditions that are compatible with gamma-secretase activity. Second, like presenilin and nicastrin, APH1A is required for the intramembrane proteolysis of both APP and Notch. Third, the down-regulation of APH1A like presenilin or nicastrin leads to concurrent reduction of the mature nicastrin or the steady-state levels of the presenilin endoproteolytic fragments, the mature presenilin species within the gamma-secretase complex.
Additional Text
Gene Name
APH1A
Uniprot ID
Q96BI3
Gene ID
51107
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 1-2 µg/ml
11-10036 Datasheet
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