Polyclonal Antibody to DUBA
Catalogue Number: 11-3014-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | OTUD5 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
Additional Text
Gene Name
OTUD5
Gene ID
55593
Purification
Protein A purified
Uniprot ID
Q96G74
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 2-4 µg/ml
11-3014 Datasheet
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