Polyclonal Antibody to IMPDHII
Catalogue Number: 11-3028-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | IMPDH2||IMPD2 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant IMPDHII protein (amino acids 86-291) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: Human type II inosine monophosphate dehydrogenase (IMPDHII) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. It is linked to cell growth, differentiation, and malignant transformation. IMPDHII also plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity. Indeed, IMPDHII increases the phosphatase activity of SHP1, which participates in the inactivation of PI3K. Enhanced expression of IMPDHII promotes the tumor metastasis and the advanced tumor progression in patients with prostate cancer.
Additional Text
Gene Name
IMPDH2
Uniprot ID
P12268
Gene ID
3615
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 1-2 µg/ml
11-3028 Datasheet
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