Polyclonal Antibody to IMPDHII
Catalogue Number: 11-3029-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | IMPDH2||IMPD2 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant IMPDHII protein (amino acids 48-351) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: IMPDH2 (Human type II inosine monophosphate dehydrogenase) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. The enzymatic reaction involves the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. It is increased more than 10-fold in activated peripheral blood T lymphocytes and is required for T cell activation. Type II isoform of the enzyme is selectively upregulated in neoplastic fast replicating lymphocytes and CML cancer cells. Thus, the IMPDH2 is an excellent target for antileukemic agent.
Additional Text
Gene Name
IMPDH2
Uniprot ID
P12268
Gene ID
3615
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 2-4 µg/ml
11-3029 Datasheet
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