Polyclonal Antibody to TAB3
Catalogue Number: 11-6001-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | TAB3||MAP3K7IP3 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | A partial length recombinant TAB3 protein (amino acids 1-350) was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3) has CUE domain and RanBP2-type zinc finger (NZF) domains mediates binding to two consecutive 'Lys-63'-linked ubiquitins. It contains 712 amino acids. TAB3 is a mediator of MAP3K7 activation and it forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation of TNF or IL-1. This successive MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor and AP1 transcription factor. This protein shows interaction with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. It has 2 isoforms produced by alternative splicing. Isoform 2 may be an oncogenic factor. TAB3 involved in necrosis and tumors like disease.
Additional Text
Gene Name
TAB3
Uniprot ID
Q8N5C8
Gene ID
257397
Purification
Protein A purified
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 4-6 µg/ml
11-6001 Datasheet
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