Polyclonal Antibody to Histone H2A.x
Catalogue Number: 11-7011-ABO
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | H2AFX||H2AX |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 ug, 25 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Full length recombinant Histone H2A.x protein was used as the immunogen for this antibody. |
| Application: | WB |
Description
Description: Histones are major chromatin proteins that wrap DNA to form nucleosome particles. Each nucleosome core particle consists of approximately 146 bp DNA wrapped by an octamer containing 2 molecules each of histones H2A, H2B, H3, and H4. Histone H1 sits on the linker DNA between nucleosomes. Their major function is to compact long DNA strands inside the nucleus and chromatin regulation. Histone H2A X is a 15 kDa variant of Histone H2. Histone H2A X is also required for the repair of double-stranded DNA breaks particularly when modified by C-terminal phosphorylation on Ser-140. Histone H2A X is expressed in all eukaryotic cells.
Additional Text
Gene ID
3014
Uniprot ID
P16104
Purification
Protein A purified
Gene Name
H2ax
Antibody Clonality
Polyclonal
Application Notes
Western blot analysis: 2-4 µg/ml
11-7011 Datasheet
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