Anti-Human CEA (2C3) Mouse IgG MoAb

Catalogue Number: 11022-IBL

Manufacturer:IBL - (Immuno-Biologicals Laboratories Co Ltd)
Physical state:Lyophilized product in PBS
Type:Monoclonal Primary Antibody - Unconjugated
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 1 mL
Host name:
Clone: 2C3
Isotype: IgG2a
Immunogen: Human CEA

Description

Description: Carcinoembryonic antigen (CEA) was reported as cancer-specific antigen existing in human colon cancer tissue and embryo intestinal tract in 1965. However it was denied that the antigen is carcinoembryonic later. CEA exists in the blood of patients with some benign disease as well as with cancer disease. The production of CEA is observed in many cancer tissues and the CEA value in the blood reflects tumor size. Therefore, the assay is widely used in a diagnosis and in monitoring of cancer. CEA is glycoprotein which has molecular weight of about 180kDa, and is detected as broad band in globlin area in electrophoresis. The bands are due to diversity of the carbohydrate portion and the carbohydrate content in CEA is 50 - 60% The CEA includes CEA related antigens which do not cross-react with CEA antisera such as NCA (non-specific cross reacting antigen) derived from lung and spleen, NCA-2 derived from the embryo stool, NFA-1 (normal fecal antigen-1) derived from the normal adult stool and NFA-2. Code No. 10094 and 11021 are CEA-specific and do not cross-react with NCA. Code No. 11022 cross-reacts to NCA Code No. 16131 and 16133 are absorbed by NCA.

Additional Text

Specificity

Cross-reacts with NCA