Recombinant Mouse Monoclonal Antibody to Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker)(Clone : rWT1/857)

Catalogue Number: 12-1011-ABO

Manufacturer:	Abeomics
Type:	Recombinant Monoclonal
Alias:	WT1, AWT1, FWT1, GUD, NPHS4, WAGR, Wilms tumor 1
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:
Clone:	rWT1/857
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human WT1 protein
Application:	IHC

Overview
Datasheets

Description

Description: Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.

Additional Text

Gene Name

WT1

Gene ID

7490

Uniprot ID

P19544

Purification

Purified

Application Notes

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1011 Datasheet

Price

£512.00

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