Anti-Bcl-2 (Apoptosis and Follicular Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rBCL2/782)

Catalogue Number: 12-1073-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Alias:	Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rBCL2/782
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human bcl-2 protein
Application:	FACS, IF, WB, IHC

Overview
Datasheets

Description

Description: This antibody recognizes a protein of 25-26kDa, identified as the bcl-2?lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression ofbcl-2?lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2?lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Additional Text

Gene Name

BCL2

Gene ID

596

Uniprot ID

P10415

Purification

Protein A/G Purified

Application Notes

Flow Cytometry (1-2µg/million cells); ,Immunofluorescence (1-2µg/ml); Western Blot (1-2µg/ml); ,Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1073 Datasheet

Price

£512.00

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