Anti-Bcl-6 (Follicular Lymphoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rBCL6/1527)

Catalogue Number: 12-1080-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rBCL6/1527
Isotype:
Immunogen:	Recombinant fragment of human bcl-6 protein (around aa 256-389) (exact sequence is proprietary)

Overview
Datasheets

Description

Description: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Additional Text

Gene ID

604

Gene Name

BCL6

Uniprot ID

P41182

Purification

Protein A/G Purified

Antibody Clonality

Monoclonal, Recombinant Monoclonal

Specificity

B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51).

12-1080 Datasheet

Price

£512.00

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