Anti-Beta-2 Microglobulin (Renal Failure &Tumor Marker) Recombinant Mouse Monoclonal Antibody (Clone:rB2M/961)
Catalogue Number: 12-1083-ABO
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12-1083 Image
12-1083 Image
12-1083 Image
Figure 1: Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Beta-2-Microglobulin Mouse Recombinant Monoclonal Antibody (rB2M/961).
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Figure 2: Formalin-fixed, paraffin-embedded Human Colon stained with Beta-2-Microglobulin Mouse Recombinant Monoclonal Antibody (rB2M/961).
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Figure 3:SDS-PAGE Analysis Beta-2-MicroglobulinMouse Recombinant Monoclonal Antibody (rB2M/961).
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | B2M; Beta 2 microglobin; Beta 2 microglobulin; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; Hdcma22p |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rB2M/961 |
| Isotype: | IgG2b, kappa |
| Immunogen: | Recombinant Full length human B2M protein |
| Application: | FACS, IF, WB, IHC |
Description
Description: Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alphaheavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alphaheavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alphaheavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Additional Text
Gene Name
B2M
Purification
Protein A/G Purified
Gene ID
567
Uniprot ID
P61769
Application Notes
Flow Cytometry (1-2µg/million cells); Immunofluorescence (1-2µg/ml); Western Blot (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Antibody Clonality
Monoclonal, Recombinant Monoclonal
12-1083 Datasheet
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