Anti-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Mouse Monoclonal Antibody (Clone:rCFTR/1342)

Catalogue Number: 12-1139-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Alias:	ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rCFTR/1342
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human CFTR protein
Application:	IHC

Overview
Datasheets

Description

Description: Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrµg resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Additional Text

Gene Name

CFTR

Uniprot ID

P13569

Gene ID

1080

Purification

Protein A/G Purified

Application Notes

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1139 Datasheet

Price

£512.00

-

Quantity
Unit Size

Find out about delivery