Anti-Cytokeratin 10 (Suprabasal Epithelial Marker) Recombinant Mouse Monoclonal Antibody (Clone:rKRT10/1275)

Catalogue Number: 12-1152-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Alias:	BCIE, BIE, EHK, Keratin Type I Cytoskeletal 10, KRT10
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rKRT10/1275
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human KRT10 protein
Application:	IHC

Overview
Datasheets

Description

Description: This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Additional Text

Gene ID

3858

Gene Name

KRT10

Uniprot ID

P13645

Purification

Protein A/G Purified

Application Notes

Immunohistochemistry (Formalin-fixed) (0.1-0.2µg/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1152 Datasheet

Price

£512.00

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