Anti-E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) Recombinant Mouse Monoclonal Antibody (Clone:rCDH1/1525)
Catalogue Number: 12-1170-ABO
12-1170 Image
12-1170 Image
12-1170 Image
Figure 1: Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525).
12-1170 Image
Figure 2: SDS-PAGE Analysis of Purified E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525).
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | Arc 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD324; CDH1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependent adhesion protein; Liver cell adhesion molecule (LCAM); Uvomorulin (UVO) |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rCDH1/1525 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant full-length human E-Cadherin protein |
| Application: | FACS, IF, WB, IHC |
Description
Description: Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Additional Text
Gene Name
CDH1
Gene ID
999
Uniprot ID
P12830
Purification
Protein A/G Purified
Application Notes
Flow Cytometry (1-2µg/million cells); Immunofluorescence (1-2µg/ml); Western Blot (1-2µg/ml); ,Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Antibody Clonality
Monoclonal, Recombinant Monoclonal
12-1170 Datasheet
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