Anti-Insulin / IRDN (beta-Cell & Insulinoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rIRDN/805)
Catalogue Number: 12-1198-ABO
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | IDDM2, ILPR, IRDN, MODY10, Proinsulin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | rIRDN/805 |
| Isotype: | IgG1, kappa |
| Immunogen: | Recombinant full-length human IRDN protein |
| Application: | IHC |
Description
Description: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected throµgh the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
Additional Text
Gene Name
INS
Gene ID
3630
Uniprot ID
P01308
Purification
Protein A/G Purified
Application Notes
Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Antibody Clonality
Monoclonal, Recombinant Monoclonal
12-1198 Datasheet
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