Anti-NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rNX2/1523)

Catalogue Number: 12-1225-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Alias:	Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rNX2/1523
Isotype:	IgG1, kappa
Immunogen:	Recombinant fragment of human NKX2.2 protein (around aa 1-119) (exact sequence is proprietary)
Application:	IHC

Overview
Datasheets

Description

Description: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

Additional Text

Purification

Protein A/G Purified

Gene Name

NKX2-2

Gene ID

4821

Uniprot ID

O95096

Application Notes

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1225 Datasheet

Price

£512.00

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