Anti-p21WAF1 (Tumor Suppressor Protein) Recombinant Mouse Monoclonal Antibody (Clone:rCIP1/823)

Catalogue Number: 12-1229-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rCIP1/823
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human CDKN1A protein
Application:	WB, IHC

Overview
Datasheets

Description

Description: This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Additional Text

Gene ID

1026

Gene Name

CDKN1A

Uniprot ID

P38936

Purification

Protein A/G Purified

Specificity

Activating Fragment 1, CAP20, CDK-interacting protein 1, CDKI, CDKN1, CDKN1A, CIP1, Cyclin-dependent kinase inhibitor 1A (p21, Cip1), DNA Synthesis Inhibitor, MDA6, Melanoma Differentiation Associated Protein 6, p21Cip1/Waf1, PIC1, SDI1, SLC12A9, Wild type p53 activated fragment 1 (WAF1)

Application Notes

Western Blot (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1229 Datasheet

Price

£512.00

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