Anti-p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody (Clone:TP53/1739)
Catalogue Number: 12-1232-ABO
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Figure 1: Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with p53 Mouse Recombinant Monoclonal Antibody (TP53/1739).
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Figure 2: SDS-PAGE Analysis of Purified p53 Mouse Recombinant Monoclonal Antibody (TP53/1739).
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| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | TP53/1739 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Recombinant full-length human TP53 protein |
| Application: | WB, IHC |
Description
Description: The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. It is a tumor suppressor protein expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast, lung, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in many malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Additional Text
Gene Name
TP53
Gene ID
7157
Uniprot ID
P04637
Purification
Protein A/G Purified
Application Notes
Western Blot (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (0.25-0.5µg/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Antibody Clonality
Monoclonal, Recombinant Monoclonal
12-1232 Datasheet
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