Anti-Thyroglobulin (Thyroidal Cell Marker) Recombinant Mouse Monoclonal Antibody (Clone:r2H11)
Catalogue Number: 12-1248-ABO
12-1248 Image
12-1248 Image
12-1248 Image
Figure 1: Formalin-fixed, paraffin-embedded human Thyroid stained with Thyroglobulin Mouse Recombinant Monoclonal Antibody (r2H11).
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Figure 2: SDS-PAGE Analysis of Purified Thyroglobulin Mouse Recombinant Monoclonal Antibody (r2H11).
| Manufacturer: | Abeomics |
| Shelf Life: | 24 months |
| Type: | Recombinant Monoclonal |
| Alias: | AITD3, hTG, TDH3, Tg, Tgn |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Host name: | Mouse |
| Clone: | r2H11 |
| Isotype: | IgG1, kappa |
| Immunogen: | Human thyroid follicular cells |
| Application: | IHC |
Description
Description: MAb r2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even thoµgh sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Additional Text
Purification
Protein A/G Purified
Gene Name
TG
Gene ID
7038
Uniprot ID
P01266
Application Notes
Immunohistochemistry (Formalin-fixed) (0.1-0.2µg/ml; 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Antibody Clonality
Monoclonal, Recombinant Monoclonal
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