Anti-TIMP1 (Colorectal Cancer Biomarker / Marker of Lymph Node Metastasis) Recombinant Mouse Monoclonal Antibody (Clone:rTIMP1/1710)

Catalogue Number: 12-1253-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rTIMP1/1710
Isotype:	IgG1
Immunogen:	Recombinant full-length human TIMP1 protein
Application:	ELISA

Overview
Datasheets

Description

Description: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.

Additional Text

Gene Name

TIMP1

Gene ID

7076

Uniprot ID

P01033

Purification

Protein A/G Purified

Application Notes

ELISA (For coating, order antibody without BSA)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

Specificity

Clgi; Collagenase inhibitor; Collagenase inhibitor, Human; EPA; EPO; Erythroid Potentiating Activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; HCI; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; TIMP 1; TIMP.

12-1253 Datasheet

Price

£512.00

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