Anti-TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) Recombinant Mouse Monoclonal Antibody (Clone:rVEGI/1283)

Catalogue Number: 12-1255-ABO

Manufacturer:	Abeomics
Shelf Life:	24 months
Type:	Recombinant Monoclonal
Alias:	TNF ligand-related molecule 1 (TL1A); Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15); Vascular endothelial growth inhibitor 192a; Vascular endothelial growth inhibitor (VEGI); VEGI192A
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	rVEGI/1283
Isotype:	IgG1, kappa
Immunogen:	Recombinant full-length human VEGI protein
Application:	IHC

Overview
Datasheets

Description

Description: VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Additional Text

Gene ID

9966

Gene Name

TNFSF15

Uniprot ID

O95150

Purification

Protein A/G Purified

Application Notes

Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

Antibody Clonality

Monoclonal, Recombinant Monoclonal

12-1255 Datasheet

Price

£512.00

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