Phospho-MCM2 (Ser139) (Clone: B12) rabbit mAb APC conjugate
Catalogue Number: 12-4332-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, CCNL1, CDCL1, KIAA0030 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 tests, 100 tests |
| Host name: | Rabbit |
| Clone: | MCM2S139-B12 |
| Isotype: | IgG1, kappa |
| Immunogen: | A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho MCM2 |
| Application: | FACS, FC |
Description
Description: The members of minichromosome maintenance (McM) protein family 2-7 were originally identified as a group of proteins essential for DNA replication (chromosomal maintenance (1,2). They share common sequence homology to each other in their nulceotide-binding domains and are distinct subgroup of the large AAA ATPase family, which are required for the initiation and elongation of DNA replication. It has been reported that Cdc7/Dbf4 phospohrylates MCM2 during G1/S cell cycle which coincides with the intiation of DNA replication (3,4)
Additional Text
Application Notes
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage Note
Store at 2-8°C. Avoid repeated freeze and thaw cycles.
12-4332 Datasheet
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