APEX1 (DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1, REF-1, Redox Factor-1, APE, APE1, APEX, APX, HAP1, REF1) (PE)

Catalogue Number: 123398-PE-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	4D1
Isotype:	IgG1, kappa
Immunogen:	Partial recombinant corresponding to aa219-318 from human APEX1 (NP_001632) with GST tag. MW of the GST tag alone is 26kD.
Application:	ELISA

Overview
Datasheets

Description

Description: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Additional Text

Gene Name

APEX1

Uniprot ID

P27695

Gene ID

328

Specificity

Recognizes human APEX1.

Purification

Protein A purified

Accession Number

NM_001641

Antibody Clonality

Monoclonal

123398-PE Datasheet

Price

£896.00

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