LRP5 (Low-density Lipoprotein Receptor-related Protein 5, LRP-5, LR3, LRP7) (Biotin)
Catalogue Number: 129208-BIOTIN-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 1e9 |
| Isotype: | IgG1, kappa |
| Immunogen: | Partial recombinant corresponding to aa41-130 from human LRP5 (NP_002326.1) with GST tag. MW of the GST tag alone is 26kD. |
| Application: | ELISA, WB |
Description
Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Additional Text
Specificity
Recognizes human LRP5.
Purification
Protein A purified
Accession Number
NM_002335
Antibody Clonality
Monoclonal
SUPPORT
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PRODUCT
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DELIVERY
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