MORG1 (Mitogen-activated Protein Kinase Organizer 1, MAPK Organizer 1, WD Repeat Domain-containing Protein 83, WDR83, MGC4238) (HRP)
Catalogue Number: 129797-HRP-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4E12 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Partial recombinant protein corresponding to aa171-262 from human MORG1 with a GST tag. MW of the GST tag alone is 26kD. |
| Application: | WB, FLISA |
Description
Description: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing.
Additional Text
Specificity
Recognizes human MORG1.
Purification
Protein A purified
Accession Number
NM_032332
Antibody Clonality
Monoclonal
129797-HRP Datasheet
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