MSI1 (Musashi-1, Musashi 1, RNA-binding Protein Musashi Homolog 1) (APC)
Catalogue Number: 129924-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3F2 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Full length recombinant corresponding to aa1-87 from human MSI1 (NP_002433) with GST tag. MW of the GST tag alone is 26kD. |
| Application: | ELISA, IF, WB, IHC |
Description
Description: Musashi 1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi 1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders. Musashi 1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.
Additional Text
Specificity
Recognizes human MSI1.
Purification
Protein A purified
Accession Number
NM_002442
Antibody Clonality
Monoclonal
129924-APC Datasheet
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