EZH2 CUTANA™ CUT&RUN Antibody

Catalogue Number: 13-2026-EPC

Manufacturer:	EpiCypher
Shelf Life:	12 months
Preservative:	0.09% sodium azide
Ph:	7-8
Physical state:	Aff. Pur. IgG
Type:	Polyclonal Primary Antibody - Unconjugated
Host Cell:	Rabbit\|Antibody
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	100 ul
Host name:	Rabbit
Clone:
Isotype:
Immunogen:	Between amino acids 696 and 746
Application:	IP, WB, CUT&RUN

Overview
Datasheets

Description

Description: This antibody meets EpiCypher's "CUTANA Compatible" criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping. Every lot of a CUTANA Compatible antibody is tested in the indicated approach using EpiCypher optimized protocols (epicypher.com/protocols) and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein. EZH2 catalyzes histone H3 lysine 27 trimethylation (H3K27me3), which leads to transcriptional repression of target genes [1]. EZH2 antibody produces CUT&RUN peaks above background primarily in intronic and intergenic regions (Figure 1) that overlap with H3K27me3 (Figure 2), consistent with its known role as the histone methyltransferase catalytic subunit of the Polycomb Repressive complex 2 (PRC2).

Additional Text

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Application Notes

CUT&RUN 0.5 µg per reaction Western Blot 1:500 - 1:2,500 Immunoprecipitation 2 - 10 µg/mg lysate

Storage Note

Stable for 1 year at 4°C from date of receipt

13-2026 Datasheet

Price

£432.00

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