PPM1A (PPPM1A, Protein Phosphatase 1A, Protein Phosphatase 2C Isoform alpha, Protein Phosphatase IA, FLJ42306, MGC9201, PP2C-ALPHA, PP2CA) (FITC)
Catalogue Number: 131665-FITC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with fluorescein isothiocyanate (FITC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4E11 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Full length recombinant corresponding to aa1-382 from human PPM1A (AAH26691) with GST tag. MW of the GST tag alone is 26kD. |
| Application: | ELISA, WB, IHC |
Description
Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Additional Text
Specificity
Recognizes human PPM1A.
Purification
Protein A purified
Accession Number
BC026691
Antibody Clonality
Monoclonal
131665-FITC Datasheet
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