PPM1A (PPPM1A, Protein Phosphatase 1A, Protein Phosphatase 2C Isoform alpha, Protein Phosphatase IA, FLJ42306, MGC9201, PP2C-ALPHA, PP2CA) (MaxLight 490)

Catalogue Number: 131665-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	4E11
Isotype:	IgG2a, kappa
Immunogen:	Full length recombinant corresponding to aa1-382 from human PPM1A (AAH26691) with GST tag. MW of the GST tag alone is 26kD.
Application:	WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Additional Text

Specificity

Recognizes human PPM1A.

Purification

Protein A purified

Accession Number

BC026691

Antibody Clonality

Monoclonal

131665-ML490 Datasheet

Price

£896.00

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Quantity
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