SORD (Sorbitol Dehydrogenase, L-iditol 2-dehydrogenase) (MaxLight 490)
Catalogue Number: 133708-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4D3 |
| Isotype: | IgG1, kappa |
| Immunogen: | Partial recombinant corresponding to aa1-110 from human SORD with GST tag. MW of the GST tag alone is 26kD. |
| Application: | WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
Additional Text
Specificity
Recognizes human SORD. Species Crossreactivity: mouse and rat.
Purification
Protein A purified
Accession Number
NM_003104
Antibody Clonality
Monoclonal
133708-ML490 Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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