STAT6 (Signal Transducer and Activator of Transcription 6, IL-4 Stat) (MaxLight 490)
Catalogue Number: 133943-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6C10 |
| Isotype: | IgG2b, kappa |
| Immunogen: | Partial recombinant corresponding to aa695-804 from human STAT6 (NP_003144) with GST tag. MW of the GST tag alone is 26kD. |
| Application: | IF, WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Upon activation by Janus kinases, Stat6 translocates to the nucleus where it regulates cytokine-induced gene expression. Stat6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13. In addition, Stat6 is activated by IFNa in B cell lines, where it forms transcriptionally active complexes with Stat2 and p48. Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling.
Additional Text
Accession Number
NM_003153
Specificity
Recognizes human STAT6.
Purification
Protein A purified
Antibody Clonality
Monoclonal
133943-ML490 Datasheet
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