(Ac-IETD)2-R110

Catalogue Number: 13431-AAT

Manufacturer:AAT Bioquest
Shelf Life:12 months
Type:Enzyme Substrates
Shipping Condition:RT
Unit(s): 1 mg

Description

Description: Since highly purified rhodamine 110 (R110)-derived substrates are locked in the lactone configuration they are colorless and non-fluorescent. Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments. R110-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. This R110 substrate is specific for caspase 8. Our R110-based substrates are highly purified to eliminate the trace amount of free R110 that is not detectable by HPLC, but causes significant assay background.

Additional Text

Storage Note

Freeze (< -15 °C); Minimize light exposure;|12 months