Adrenocorticotrophic Hormone (ACTH, Corticotropin)

Catalogue Number: 138494-USB

Manufacturer:	United States Biological
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug
Host name:	Mouse
Clone:	AH26
Isotype:	IgG1, kappa
Immunogen:	Synthetic peptide corresponding to aa1-24 from human ACTH.
Application:	ELISA, FC, IF, IP, WB, IHC

Overview
Datasheets

Description

Description: ACTH (Adrenocorticotrophic hormone) is produced and secreted by the anterior pituitary gland, and is a key component of the hypothalamic-pituitary-adrenal axis. ACTH is synthesized from the precursor molecule pre-opiomelanocorin (POMC). POMC undergoes proteolytic cleavages and processing to generate not only ACTH but also a number of other small biologically active peptides including alpha-MSH and beta-endorphin, all in cell type specific manners. The production of ACTH is triggered by biological stress. ACTH, in turn, then stimulates the secretion of corticosteroids by the adrenal cortex. The half-life of ACTH in human blood is only about ten minutes. An excess of ACTH can cause Cushing's syndrome whereas ACTH deficiency can result in secondary adrenal insufficiency. ACTH consists of 39aa, and can be proteolytically cleaved into different active fragments including CLIP (corticotropin-like intermediate lobe peptide), consisting of aa17-39, which stimulates insulin production. Synacthen is an active synthetic form of ACTH, corresponding to the first 24aa, which is used to conduct ACTH stimulation tests. The antibody is superb for staining routine formalin-fixed, paraffin-embedded tissues. The antibody labels corticotrophs in the adenohypophysis. The antibody is useful in the classification of pituitary adenomas. Likewise, the antibody can be used in the differential identification of primary and metastatic tumors of the pituitary.

Additional Text

Gene Name

POMC

Accession Number

NP_000930

Purification

Protein G purified

Gene ID

5443

Uniprot ID

P01189

Antibody Clonality

Monoclonal

138494 Datasheet

Price

£625.00

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