Bcl-2 (Apoptosis regulator Bcl-2, B Cell CLL/lymphoma-2) (MaxLight 490)
Catalogue Number: 138498-AF-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 8C8 |
| Isotype: | IgG1, kappa |
| Immunogen: | Synthetic peptide corresponding to aa41-54 (GAAPAPGIFSSQPG-Cys) from human Bcl-2. |
| Application: | IF, IP, WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. This antibody recognizes a protein of 25-26kD, identified as the bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Additional Text
Accession Number
NP_000624
Purification
Protein A/G Purified
Specificity
Recognizes human Bcl-2. Species Crossreactivity: monkey and porcine. Does not react with mouse or rat.
Antibody Clonality
Monoclonal
138498-AF-ML490 Datasheet
SUPPORT
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