CD56 (Neural Cell Adhesion Molecule, NCAM) (MaxLight 490)
Catalogue Number: 138521-AF-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 123C3.D5 |
| Isotype: | IgG1, kappa |
| Immunogen: | Membrane preparation of a small cell lung carcinoma. Cellular Localization: Cell surface |
| Application: | FC, IF, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. CD56, a 175-220KD glycoprotein, is a member of the Ig super family. It is expressed as three major isoforms and consists of five Ig-like domains and two Fibronectin-type III domains in the extracellular region. The 135kD isoform is the basic molecule which is glycosylated or sialylated to produce the mature species. CD56 is widely expressed in nervous system, on NK cells and a specific set of Tcells. CD56+ NK cells and Tcells are unique in their ability to mediate cell-mediated cytotoxicity against certain tumor cell targets without MHC restriction. Other physiological functions of CD56 include mediating cell adhesion through homophilic and heterophilic interaction and activating intracellular signaling pathways resulting in neutrite extension and fasciculation, migration and synapses formation in brain. CD56 is also vital for neuronal development and plasticity in adult brain. It is used as a tumor marker in various cancers such as NK lymphomas and Merkel cell carcinoma. NCAM is expressed on most neuroectodermal derived lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells.
Additional Text
Gene Name
NCAM1
Gene ID
4684
Uniprot ID
P13591
Accession Number
NP_000606
Purification
Protein A/G Purified
Specificity
Recognizes human CD56. Species Crossreactivity: rat and zebrafish. Recognizes two proteins (185kD & 145kD), identified as two isoforms of neural cell adhesion molecule (NCAM/CD56).
Antibody Clonality
Monoclonal
138521-AF-ML490 Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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