Cytokeratin, pan (Pan Keratin) (BSA & Azide Free) (MaxLight 490)

Catalogue Number: 138538-AF-ML490-USB

Manufacturer:	United States Biological
Preservative:	BSA & Azide Free
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CK-1B\|cytokeratin-1B\|K1B\|K77\|keratin 1B\|keratin 77, type II\|keratin, type II cytoskeletal 1b\|KRT1B\|type-II keratin Kb39
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	AE-1/AE-3
Isotype:	IgG1, kappa
Immunogen:	Human epidermal keratin. Cellular Localization: Cytoplasmic
Application:	FC, IF, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1, CK3, CK4, CK5 , CK6, CK8, CK10, CK14, CK15, CK16, and CK19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing ce lls in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.

Additional Text

Purification

Protein A/G Purified

Gene Name

KRT77

Specificity

Recognizes human pan Cytokeratin. Species Crossreactivity: monkey, bovine, canine, rabbit, mouse, rat, chicken. Recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1 (67kD), CK3 (64kD), CK4 (59kD), CK5 (58kD), CK6 (56kD), CK8 (52kD), CK10 (56.5kD), CK14 (50kD), CK15 (50kD), CK16 (48kD), and CK19 (40kD).

Gene ID

374454

Uniprot ID

Q7Z794

Antibody Clonality

Monoclonal

138538-AF-ML490 Datasheet

Price

£883.00

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Quantity
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