Estrogen Receptor, beta (ES) (MaxLight 490)
Catalogue Number: 138550-AF-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | ERb455 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant protein corresponding to human Estrogen Receptor beta at C-terminus. |
| Application: | IF, IP, WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Additional Text
Gene Name
ESR2
Gene ID
2100
Uniprot ID
Q92731
Accession Number
NP_001035365
Specificity
Recognizes human Estrogen Receptor beta. Species Crossreactivity: monkey, mouse, rat, porcine, equine and sheep.
Purification
Protein G purified
Antibody Clonality
Monoclonal
138550-AF-ML490 Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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