Myogenin, NT (MYOG, BHLHC3, MYF4, Myogenin, Class C basic helix-loop-helix protein 3, Myogenic factor 4) (MaxLight 490)
Catalogue Number: 138574-AF-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | bHLHc3|class C basic helix-loop-helix protein 3|MYF4|myf-4|myogenic factor 4|myogenin |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | MGN185 |
| Isotype: | IgG1, kappa |
| Immunogen: | Recombinant protein corresponding to human myogenin. |
| Application: | IF, IP, WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70aa in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% aa homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms' tumor.
Additional Text
Gene ID
4656
Gene Name
MYOG
Uniprot ID
P15173
Accession Number
NP_002470
Specificity
Recognizes human myogenin. Species Crossreactivity: mouse, rat, feline and porcine.
Purification
Protein G purified
Antibody Clonality
Monoclonal
138574-AF-ML490 Datasheet
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