NKX2.2 (Homeobox protein NKX) (MaxLight 490)

Catalogue Number: 138578-AF-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	homeobox protein NK-2 homolog B\|homeobox protein Nkx-2.2\|NK2 transcription factor related, locus 2\|NK2 transcription factor-like protein B\|NKX2.2\|NKX2B
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	NX2/294
Isotype:	IgG2b, kappa
Immunogen:	Recombinant protein corresponding to human NKX2.2.
Application:	IF, IP, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

Additional Text

Accession Number

NP_002500

Purification

Protein A/G Purified

Gene Name

NKX2-2

Specificity

Recognizes human NKX2.2.

Uniprot ID

O95096

Gene ID

4821

Antibody Clonality

Monoclonal

138578-AF-ML490 Datasheet

Price

£883.00

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Quantity
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