p21 (Cyclin-dependent Kinase Inhibitor, CDK-interacting Protein 1, WAF1) (MaxLight 490)

Catalogue Number: 138579-AF-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	WA-1 (HJ21)
Isotype:	IgG1, kappa
Immunogen:	Recombinant protein corresponding to human p21.
Application:	IF, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. This monoclonal antibody recognizes a 21kD protein, identified as the p21WAF1 tumor suppressor protein. This monoclonal antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Additional Text

Gene ID

1026

Gene Name

CDKN1A

Uniprot ID

P38936

Accession Number

NP_000380

Specificity

Recognizes human p21. Species Crossreactivity: monkey, mouse and rat. Does not cross-react with other closely related mitotic inhibitors.

Purification

Protein G purified

Antibody Clonality

Monoclonal

138579-AF-ML490 Datasheet

Price

£883.00

-

Quantity
Unit Size

Find out about delivery