p53 (Tumor Suppressor Protein, Oncogene Protein) (MaxLight 490)

Catalogue Number: 138582-AF-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	antigen NY-CO-13\|BCC7\|BMFS5\|cellular tumor antigen p53\|LFS1\|mutant tumor protein 53\|P53\|p53 tumor suppressor\|phosphoprotein p53\|transformation-related protein 53\|TRP53\|tumor protein 53\|tumor supressor p53
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	BP53-12
Isotype:	IgG2a
Immunogen:	Full length recombinant protein corresponding to human p53.
Application:	IF, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Recognizes a 53kD protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, re plication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Additional Text

Gene Name

TP53

Gene ID

7157

Uniprot ID

P04637

Accession Number

NP_000537

Specificity

Recognizes human p53. Does not cross-react with mouse or rat.

Purification

Protein G purified

Antibody Clonality

Monoclonal

138582-AF-ML490 Datasheet

Price

£883.00

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