Renal Cell Carcinoma (RCC) (MaxLight 490)

Catalogue Number: 138592-AF-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CAIX\|CA-IX\|carbonate dehydratase IX\|carbonic anhydrase 9\|carbonic anhydrase IX\|carbonic dehydratase\|membrane antigen MN\|MN\|P54/58N\|pMW1\|RCC-associated antigen G250\|RCC-associated protein G250\|renal cell carcinoma-associated antigen G250
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	66.4.C2, PN-15
Isotype:	IgG2b, kappa
Immunogen:	Microsomal fraction of human renal cortical tissue homogenate
Application:	IF, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Recognizes a glycoprotein of ~200kD, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This monoclonal antibody may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

Additional Text

Gene ID

768

Gene Name

CA9

Uniprot ID

Q16790

Accession Number

NP_001207

Specificity

Recognizes human Renal Cell Carcinoma. Species Crossreactivity: equine.

Purification

Protein G purified

Antibody Clonality

Monoclonal

138592-AF-ML490 Datasheet

Price

£883.00

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