TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (MaxLight 490)
Catalogue Number: 138595-AF-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CELE_C25A1.3|mRNA cap guanine-N7 methyltransferase |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | B72.3 |
| Isotype: | IgG1, kappa |
| Immunogen: | Membrane-enriched fraction of a human breast carcinoma liver metastasis |
| Application: | IF, IP, WB, IHC, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Recognizes an oncofetal antigen of 220kD, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This monoclonal antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.
Additional Text
Accession Number
NP_492674
Specificity
Recognizes human TAG-72. Species Crossreactivity: bovine, canine, hamster and rat. Stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.
Purification
Protein G purified
Gene ID
182875
Uniprot ID
Q9XVS1
Gene Name
tag-72
Antibody Clonality
Monoclonal
138595-AF-ML490 Datasheet
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