Tyrosinase (TYR) (MaxLight 490)

Catalogue Number: 138600-AF-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	ATN\|CMM8\|LB24-AB\|monophenol monooxygenase\|OCA1\|OCA1A\|OCAIA\|oculocutaneous albinism IA\|SHEP3\|SK29-AB\|tumor rejection antigen AB\|tyrosinase
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	T311
Isotype:	IgG2a, kappa
Immunogen:	Recombinant protein corresponding to tyrosinase.
Application:	IF, IP, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Recognizes a cluster of proteins between 70-80kD, identified as tyrosinase. Occasionally a minor band at 55kD is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.

Additional Text

Gene ID

7299

Gene Name

TYR

Uniprot ID

P14679

Accession Number

NP_000363

Specificity

Recognizes human tyrosinase, 70-80kD. Does not cross-react with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas showed tyrosinase in melanotic as well as amelanotic variants.

Purification

Protein G purified

Antibody Clonality

Monoclonal

138600-AF-ML490 Datasheet

Price

£883.00

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Quantity
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