Dengue Virus, NS1
Catalogue Number: 143059-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in 0.01M PBS, pH 7.2, 0.09% sodium azide. No stabilizing proteins added. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg |
| Host name: | Mouse |
| Clone: | 13k22 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to Dengue Virus NS1 (mixture of serotypes 1, 2, 3 & 4). |
| Application: | ELISA, IF, LF |
Description
Description: NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.
Additional Text
Caution
FOR RESEARCH USE ONLY
Specificity
Recognizes NS1 protein of all 4 serotypes of Dengue Virus.
Purification
Protein A purified
Antibody Clonality
Monoclonal
143059 Datasheet
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