AMIGO-1 (Amphoterin-induced protein 1, Alivin-2, Ali2, AMIGO and KIAA1163)

Catalogue Number: 167573-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS pH7.4, 50% glycerol.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	ALI2\|alivin-2\|AMIGO\|AMIGO-1\|amphoterin-induced gene and ORF\|amphoterin-induced protein 1
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	S86-36
Isotype:	IgG1
Immunogen:	Fusion protein amino acids 554-574 (cytoplasmic C-terminus) of human AMIGO-1, Accession# Q86WK6
Application:	ICC, WB, IHC

Overview
Datasheets

Description

Description: The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. They can form complexes with each other, but can also self-bind. AMIGO1, also designated Alivin2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin3) plays a role in hemophilic and/or heterophilic cell-cell interaction and signal transduction.

Additional Text

Caution

FOR RESEARCH USE ONLY

Accession Number

NP_065754.2

Uniprot ID

Q86WK6

Specificity

Recognizes human AMIGO-1. Species Crossreactivity: Mouse, Human, Rat. Detects 60-80kD depending on maturity/glycosylation

Purification

Protein G purified

Gene ID

57463

Gene Name

AMIGO1

Antibody Clonality

Monoclonal

167573 Datasheet

Price

£568.00

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