Notch1 (Neurogenic locus notch homolog protein 1, hN1, Translocation associated notch protein, TAN-1, Motch A, mT14, p300 and Motch)

Catalogue Number: 167601-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS pH7.4, 50% glycerol.
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	9930111A19Rik\|lin-12\|major type A protein\|Mis6\|Motch A\|mT14\|N1\|neurogenic locus notch homolog protein 1\|Notch gene homolog 1\|p300\|Tan1\|transmembrane receptor Notch1
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	S253-32
Isotype:	IgG1
Immunogen:	Fusion protein amino acids 20-216(extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1, Accession# Q01705.
Application:	ICC, WB

Overview
Datasheets

Description

Description: Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

NOTCH1

Uniprot ID

Q01705

Accession Number

NP_032740.3

Specificity

Recognizes mouse Notch1. Species Crossreactivity: Rat, Mouse. Detects >270kD, ~120kD and small fragments due to proteolysis. Does not cross-react with Notch 2 or Notch3.

Purification

Protein G purified

Gene ID

18128

Antibody Clonality

Monoclonal

167601 Datasheet

Price

£568.00

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