Gi24 (VISTA, B7-H5, C10orf54, Dies1, Gi24, SISP) (PE)

Catalogue Number: 167655-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	730804
Isotype:	IgG2b
Immunogen:	Recombinant protein corresponding to Phe33-Ala194 of human Gi24 expressed in NS0 cells.
Application:	FC

Overview
Datasheets

Description

Description: Platelet Receptor Gi24, also known as VISTA (V-domain Ig suppressor of T cell activation), B7-H5, B7H5, Dies1 (Differentiation of ESC-1), SISP1 and C10orf54, is a 55-65kD member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30kD extracellular fragment plus a 25-30kD membrane-bound fragment. Over aa33-194, human Gi24 shares 70% and 67% aa identity with mouse and rat Gi24, respectively.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes human Gi24. No cross-reactivity with recombinant mouse Gi24 in Direct ELISA.

Uniprot ID

Q9H7M9

Gene ID

64115

Purification

Protein A purified

Gene Name

VSIR

Antibody Clonality

Monoclonal

167655 Datasheet

Price

£806.00

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