Esrp-1/2 (Rbm35a, Epithelial splicing regulatory protein 1, RNA-binding protein 35A, RNA-binding motif protein 35A, RNA-binding protein 35B, RNA-binding motif protein 35B.)

Catalogue Number: 168168-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	14B12
Isotype:	IgG1
Immunogen:	Recombinant protein corresponding to full length mouse Esrp-1 fusion protein.
Application:	ELISA, WB

Overview
Datasheets

Description

Description: Epithelial splicing regulatory protein-1 (Esrp-1) and Esrp-2 are mRNA splicing factors that regulate the formation of epithelial cell-specific isoforms. They specifically regulate the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 and -2 act by directly binding specific sequences in mRNAs. They bind the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes mouse Esrp-1/2.

Purification

Protein A purified

Antibody Clonality

Monoclonal

168168 Datasheet

Price

£922.00

-

Quantity
Unit Size

Find out about delivery