Bcl-2 (Apoptosis regulator Bcl-2, B Cell CLL/lymphoma-2) (MaxLight 490)
Catalogue Number: 168647-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 100/D5+124 |
| Isotype: | IgG1, kappa |
| Immunogen: | Synthetic peptide corresponding to aa41-54, GAAPAPGIFSSQPG-Cys, from human Bcl-2. Cellular Localization: Outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. |
| Application: | IF, IP, WB, IHC |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Additional Text
Gene Name
BCL2
Gene ID
596
Uniprot ID
P10415
Purification
Protein A/G Purified
Specificity
Recognizes human Bcl-2. Does not react with mouse and rat. Does not react with Bcl-x or Bax protein.
Antibody Clonality
Monoclonal
168647-ML490 Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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